Novel lysophosphoplipid receptors: their structure and function
نویسندگان
چکیده
منابع مشابه
Structure and function of Toll receptors and their ligands.
The Toll family of class I transmembrane receptors recognizes and responds to diverse structures associated with pathogenic microorganisms. These receptors mediate initial responses in innate immunity and are required for the development of the adaptive immune response. Toll receptor signaling pathways are also implicated in serious autoimmune diseases such as endotoxic shock and thus are impor...
متن کاملBAFF, APRIL and their receptors: structure, function and signaling.
BAFF, APRIL and their receptors play important immunological roles, especially in the B cell arm of the immune system. A number of splice isoforms have been described for both ligands and receptors in this subfamily, some of which are conserved between mouse and human, while others are species-specific. Structural and mutational analyses have revealed key determinants of receptor-ligand specifi...
متن کاملNew Frontier in Glycoprotein Hormones and Their Receptors Structure–Function
Last two decades of structure-function studies performed in numerous laboratories provided substantial progress in understanding basic science, physiological, pathophysiological, pharmacological, and comparative aspects of glycoprotein hormones (GPHs) and their cognate receptors. Multiple concepts and models developed based on experimental data in the past stood the test of time and have been, ...
متن کاملStructure, function, and regulation of adrenergic receptors.
Adrenergic receptors for adrenaline and noradrenaline belong to the large multigenic family of receptors coupled to GTP-binding proteins. Three pharmacologic types have been identified: alpha 1-, alpha 2-, and beta-adrenergic receptors. Each of these has three subtypes, characterized by both structural and functional differences. The alpha 2 and beta receptors are coupled negatively and positiv...
متن کاملStructure and function of reconstituted AMPA receptors
Background: Ionotropic glutamate receptors mediate fast excitatory synaptic transmission in the vertebrate CNS. Results: Conformational flexibility and dimensions of functional membrane-embedded full-length GluA2flop receptors are characterized by atomic force microscopy. Conclusion: Conformational flexibility and dimensions are both strongly affected by receptor density. Significance: The reco...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Lipid Research
سال: 2014
ISSN: 0022-2275
DOI: 10.1194/jlr.r046920